19 December 2007
It started, as it nearly always does, with lameness. In Branigan's case, there was perhaps a degree of luck (if that's the right word) - already lame in his left hind leg following a
spinal injury as a puppy, going lame in his right foreleg created a 'double limp' which was impossible to miss or overlook. Initially though, in spite of his litter brother having died of bone cancer six months earlier, we assumed (hoped) it was just a sprain or a pulled muscle due to his habit of charging down hills at full speed. We gave him Metacam, and grounded him.
Branigan's bone cancer
20 December 2007
After 24 hours there was no improvement, and he was having great difficulty in getting about the house. Stretched out with him on the sofa that evening, I could feel an irregularity in one of the bones on the back of his lower right leg. Like probing a sore tooth, I kept feeling for it, hoping that I had imagined it and would be unable to locate the area the next time I looked . . .

21 December 2007

10.00 am: vet appointment. Branigan examined, and kept in for x-rays. 2.00 pm: phone call from the vet, Branigan still anaesthetised in case we decide on the unthinkable. Diagnosis: osteosarcoma. Amputation not an option due to his pre-existing lameness. But . . . it was at a very early stage, his blood calcium was barely raised, and our vet felt there was no danger of imminent fracture.

And here we have to digress, because some three months earlier whilst staying at our second home in the UK, we attended the local vet with one of the dogs for a minor injury. There, we were delighted to meet another wolfhound, seven year old
Milo, but saddened to hear from his owners, Chris and Debbie, that he had just been diagnosed with bone cancer. We chatted, sympathised, and later met up for a full-scale wolfhound fest. We kept in touch and knew that Milo was being treated with Fosamax (alendronate acid). Although on high doses of analgesia, he was still well in himself and mobile enough to enjoy short walks.

Back to the phone call from our vet: Had he ever heard of Fosamax? No, but he willing for us to try anything - we, and Bran, had nothing to lose. OK, then - wake him up, please!

As it happened, we were booked on the ferry to the UK that evening for our Christmas stay in the UK, and we were able to make an appointment with Milo's vet for immediately after the Christmas holiday.
Meanwhile, Bran was given Duragesic (fentanyl)  patches for pain control, and we collected the poor, bewildered, still groggy boy from the surgery en route to the car ferry check-in.

22 - 26 December 2007
The Duragesic did a good job of controlling Bran's pain and his limp virtually disappeared (the new one, anyway), so that he was still able to manage holiday walks with the others.

Unfortunately, the analgesic patches had a definite effect on his mood, and he was certainly not his usual lively, laughing self over the holiday.
27 December 2007
Milo's vet was happy to commence Branigan on Fosamax, together with
Tramadol and Metacam for pain control.  He confirmed our vet's opinion that the cancer is in its very early stages, and felt that we could reasonably expect to enjoy Bran's company for another six months or so.

We are taking life a day at a time, and plan to continue Bran's normal routine of walks, games and fun for as long as he is able to enjoy himself, our main aim being to maintain his quality of life rather than extend the length of it.





5 January 2008

Thanks to contacts from some kind friends, Branigan has now been seen by a
veterinary oncologist (cancer specialist). During an hour's consultation we were given several options to consider, the most radical being limb-saving surgery, in which the malignant area of bone is replaced with a graft. Had the success rate been reliable we might have been tempted, but neither of us wanted to put Bran through the stress and trauma of such major surgery without more certainty of success.

However, once we return home to Guernsey next week, he will commence on treatment with
Zometa (zoledronic acid) a drug which works in a similar way to Fosamax but has been thought to be more effective. Provided his chest x-ray is clear of secondary growths, he will also commence chemotherapy in the form of carboplatin.

We are hopeful that this new regime will maximise both the quality and quantity of Bran's life.
The plan is for a further five chemo treatments at three weekly intervals, the dose depending on the level of his white cell count, and Zometa injections every four weeks for the foreseeable future.

Information on the research being carried out by Tom Cave, our oncologist vet, can be found
here in an article written for the Greyhound Rescue Trust. We have submitted Bran's blood samples to the Animal Health Trust research programme, and also a study being carried out in Sweden.

Right now, you wouldn't know there was anything wrong with him at all. His pain appears to be well controlled on a low dose of tramadol and daily Metacam, he has no lameness in the affected leg and is enjoying at least one good off-lead walk a day with the rest of the pack. He is as mulish and infuriatingly wicked as ever - long may it continue!
10 January 2008
Branigan's chest x-ray yesterday was clear of secondaries, so he had his first dose of chemotherapy and also started treatment with Zometa. Further x-rays of the tumour confirm that pathological fracture is very unlikely at this stage, and ultimately the Zometa should strengthen the bone sufficiently to prevent it occurring at all.
30 January 2008
Following his first dose of chemotherapy Branigan's white cell count remained within normal limits for a sight-hound - they tend to be lower than other dogs. Thankfully, he appeared to suffer no ill effects from the treatment whatosever.

He has continued to be pain-free and fully mobile - walking, romping and helping the girls chase a few rabbits.

The time for the second of his six doses of chemo- therapy had come. Due to space restrictions at our local vet's surgery he was lucky enough to have this administered at home, from the comfort of his own sofa.
"We're ready - where's the coffee?!"
"Just hold still - this won't hurt a bit!"
Vet David Chamberlain and nurse Nicky Le Galloudec of Isabelle Vets made short work of turning our dining room table into a make-shift surgery, and kitting themselves out in the protective gear necessary for the safe handling of cytotoxic drugs. The session went without a hitch and Bran was the perfect patient (thanks to just a little touch of sedation to keep him cool and calm!)
It takes seven years' training to produce a fully qualified human drip-stand!
15 February 2008
We know some people are a little doubtful that Branigan really can be doing as well as we claim, so we'll let the boy show you himself. Here are two video clips of him in action, taken this week, nearly two months after he was diagnosed:
20 March 2008
For those of you interested in the technical stuff, we've been sent
this report on a US study into the use of Zometa. The positive findings are firmly supported by Branigan in this video clip taken a few days ago.
23 April 2008
Over the last month we have started to see some changes in Bran. There is now visible thickening of the bone in the affected area, and although the particular chemotherapy that he is on is not supposed to cause hair loss, he's developed the rather moth-eaten, skinny-legged look that very old wolfhounds often have, on his front legs in particular.

He sometimes exhibits lameness and a reluctance to go on walks a few days before his monthly Zometa injection is due, but this responds to a small increase in the dose of his analgesia and the Zometa itself, which appears to be crucial in controlling his pain.

Today, he completed the full course of six doses of chemotherapy, but will continue on Zometa for the duration. We have been told by his cancer specialist that on the chemo/Zometa treatment regime the average lifespan after diagnosis is eight months; the maximum is ten. What is likely to happen is that Bran will continue more or less as he is now until the tumour invades the soft tissue of the leg, at which point the Zometa will cease to be effective and the sudden increase in pain and lameness will bring us to the inevitable end of his story.
. . . and April 2007
April 2008
18 May 2008
It's five months now since Braningan's bone cancer was diagnosed. On some days he's quite subdued, and we begin to think that it's starting to take its toll . . . and on other days, well, see for yourselves in these short video clips:
20 June 2008
Six months . . . the thickening of the bone in the affected area is more pronounced, but remains cleanly encapsulated with no apparent spread to the surrounding tissues.
The combination of Metacam/ Tramadol/Zometa is still giving him excellent pain control, apart from the week prior to his Zometa treatment when we increase his Tramadol and reduce his walks slightly.
In himself, he's as cheerful, as mulish and as extrovert as ever . . .
1 July 2008
Last weekend, Bran had the time of his life on one of his favourite beaches, as you can see by clicking on the photo. Not surprisingly, he was in considerable pain the next day, and we increased his dose of tramadol and rested him, confident that, as has happened before, he would bounce back. He didn't.

By the end of last week we had doubled his tramadol (400mg, twice daily) but it was clear that he still had a great deal of pain in the affected leg. His mobility around the house was severely reduced, though on short walks he would skip along at a fair old rate, determined to enjoy himself.
Bran has a ball!
On Friday evening, we made a considered decision to give him the weekend, and if there was no improvement we would ask our vet to visit to complete the last episode in this story on Monday. Branigan didn't make this decision any easier for us by remaining cheerful throughout the weekend, and making the most of the extra treats and attention that he received.
















Over and again we questioned whether we were right, whether we should give him a few more weeks, a few more days . . . he was still so bright in himself at times. But we knew he was in pain, and it was only his bull-headed obstinacy and innate good humour that were keeping him going. If we waited, what were we waiting for? For him to become ill and depressed? That would be too late. We had said all along that this was not an exercise in seeing how long he could last - left to himself, his determination and fighting spirit would take him to the wire. Our job was to prevent his having to do that.

It was with a heavy heart on Monday morning that we contacted our vet, David Chamberlain, who has seen Bran through both his FCE and his bone cancer. He came within the hour and, with Branigan comfortable and relaxed on his favourite sofa, his mum and dad at his side and the other dogs nearby, David brought Bran's pain to an end. Swiftly, quietly and peacefully, his great, loving heart came to a standstill.


We don't have the words to express our sorrow, nor how much we will miss this laughing, obstinate, brave, wonderful buffoon of a dog. From his position as second-in-command he has totally dominated the pack for the last five years, and commanded our hearts with equal ease. He leaves behind a home with three wolfhounds . . . how can it feel so empty?




We wish to thank everyone who has taken the time and trouble to send messages of support and sympathy throughout Bran's illness - we value and appreciate every one.

Most especially though, our thanks go to Julia McKendry and Sue Bevis who, in the dark days after Bran's diagnosis, recommended that we contact Gill Griffin; to Gill herself, who put us in touch with Tom Cave and his team at
Cave Referrals, and finally to our own, very special vet, David Chamberlain of Isabelle Vets, and vet nurse, Nicky Le Galloudec, both of whom have given us and Bran tremendous support and encouragement throughout his battle.




Finally, on a more prosaic note - insurance. Like many wolfhound owners, we wince and groan every year when the dogs' insurance premiums fall due and love to moan about insurance companies. So we would like to place on record our thanks to
Petplan for their prompt response to every claim we have made for Branigan's treatment. From the day he was diagnosed, this has amounted to some £8,000 (approx. $16,000 or €10,000) which Petplan have paid promptly, in full and without quibble or question.
Click on the pic for Bran's last romp
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